The research team was led by Professor David Melzer, Professor of Epidemiology and Public Health at PCMD, University of Exeter. Other studies related to BPA carried out by the same research team have found associations with altered testosterone and changes in the expression of BPA target genes in men, suggesting that BPA may be more active in the body than previously thought. This is the fourth study led by PCMD, University of Exeter to identify a statistical link between increased levels of urinary BPA and cardiovascular disease. The results are important because they suggest that associations between urinary BPA and CAD may be specific to narrowing of the arteries. The study shows that urinary BPA concentration was significantly higher in those with severe CAD compared to those with normal coronary arteries. In all, 385 patients were identified to have severe CAD, 86 intermediate CAD and 120 had normal coronary arteries. The patients were classified into severe, intermediate or normal CAD categories based on narrowing of their coronary arteries measured using a technique called angiography, which is considered the gold standard method of diagnosis. They compared urinary BPA with grades of severity of coronary artery disease (CAD). The team analysed data from 591 patients who participated in the Metabonomics and Genomics Coronary Artery Disease (MaGiCAD) study in Cambridgeshire, UK. The study is published in PLoS ONE today, 15th August 2012.
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